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Vitamin B12, the “antipernicious anemia factor” required for human and animal metabolism, was discovered in the late 1940s. B12-derivatives are cobalt complexes of the unique and remarkably complex corrin ligand, that belongs to the class of the natural tetrapyrroles. The B12-coenzymes are the organometallic cofactors in various important enzymatic reactions and are particularly relevant in the metabolism...
The geochemical theory of the origin of life proposes that primordial, pre-biotic reactions were carried out in a metal-sulfide-rich environment similar to that found near hot springs at the ocean floor. Many contemporary experiments have shown that reactions reminiscent of those carried by extant anaerobic microorganisms involving gases such as CO, CO2 and H2, can indeed take place abiotically in...
The possible formation of carbene complexes of cytochromes P450 enzymes in various metabolisms of xenobiotics is first described. In view of these observations, the organometallic chemistry of iron porphyrins, serving as a basis for elucidating the mechanism of these enzymes is then presented, emphasizing the biological relevance. The chemistry of metalloporphyrin models has been extended to ruthenium...
Trinuclear organometallic macrocycles are able to complex amino acids and peptides in aqueous solution. The complexation, which is driven by hydrophobic and π − π interactions, induces a large shift of the 1H NMR signals of the guest. The organometallic host can thus be employed as an NMR shift reagent. Structurally related trinuclear macrocycles selectively bind lithium and fluoride ions in protic...
This chapter sketches an outline of ferrocene–peptide bioconjugates. A variety of ferrocene–peptide bioconjugates have been designed to induce highly ordered structures of peptides and develop new biomaterials. The ferrocene serves as a reliable organometallic scaffold for the construction of an ordered structure via intramolecular hydrogen bonding, wherein the attached peptide strands are regulated...
Although organometallic compounds are ubiquitous in nature, synthetic organometallic compounds are generally considered to be toxic or non-compatible with biological systems. Despite this perception the medicinal properties of organometallic compounds, in particular organo-transition metal compounds, have been probed for a long time and in the last few years the area has grown considerably. In this...
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